Romelu Lukaku did not take part in Belgium training on Tuesday as he deals with an ankle injury.
Head coach Roberto Martinez revealed after the 5-2 win over Tunisia on Saturday that Lukaku, who scored two goals to take his tally for the World Cup to four, sustained “external ankle ligament damage to his left foot”.
The Manchester United striker went for a scan on Monday and did not feature in group activities with his team-mates the following day in Dedovsk. However, Eden Hazard and Dries Mertens, struggling with calf and ankle problems respectively, did participate.
Belgium have already qualified for the last 16 at Russia 2018, but top spot in Group G will be up for grabs when they take on England in Kaliningrad on Thursday.
Martinez has expressed his intention to make widespread changes to his line-up, with it appearing unlikely Lukaku will be risked against the Three Lions.
Vincent Kompany was anticipated to be ready for action against England and has been declared “medically fully fit” by the Red Devils coach.
Kevin De Bruyne, Jan Vertonghen and Thomas Meunier are a booking away from a suspension and could therefore be among the players rested against England.
Belgium have thus far thumped Tunisia and beaten Panama 3-0. England beat Tunisia 2-1, and thrashed Panama 6-1.